Preclinical study on protection strategy and function recovery strategy of preimplantation for marginal graft

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293355
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Fujita Health University
• Principal Investigator: Kusaka Mamoru 藤田保健衛生大学, 医学部, 教授 (40309141)
• Co-Investigator(Kenkyū-buntansha): 山田 和彦 鹿児島大学, 学内共同利用施設等, 教授 (40241103) ; 佐原 寿史 鹿児島大学, 学内共同利用施設等, 准教授 (90452333)
• Co-Investigator(Renkei-kenkyūsha): HOSHINAGA Kiyotaka 藤田保健衛生大学, 医学部, 教授 (30229174)
• Research Collaborator: MIURA Kouhei ; KAWAI Akihiro ; WAKI Shiori
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 移植・再生医療 / 腎移植 / 常温腎臓持続体外灌流保存 / マージナルドナー / 臓器保護 / 前臨床実験 / ミニブタ

Outline of Final Research Achievements

In this study, we focused on agents with various cytoprotective effects on marginal donor kidneys where activation of inflammatory precursors caused tissue injury. Using established MHC miniture swine which can evaluate detailed immune reaction, we investigated the effect of organ protection and repair by drug administration to donor, recipient, graft persistent perfusion preservation. We conducted experiments to establish a strategy to restore and recover marginal donor organs to conditions comparable to living organs.

Free Research Field

移植・再生医療