Fundamental research of host immune-genomics and development of new cancer therapy for ovarian cancer

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293359
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Kyoto University
• Principal Investigator: Hamanishi Junzo 京都大学, 医学(系)研究科(研究院), 講師 (80378736)
• Co-Investigator(Kenkyū-buntansha): 松村 謙臣 京都大学, 医学(系)研究科(研究院), 准教授 (20452336) ; 安彦 郁 京都大学, 医学(系)研究科(研究院), 助教 (20508246) ; 小西 郁生 京都大学, 医学(系)研究科(研究院), 教授 (90192062)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: がん免疫逃避 / Immuno-genomics / がん免疫療法 / 卵巣がん / 免疫チェックポイント阻害薬 / PD-L1 / PD-1

Outline of Final Research Achievements

To investigate the host immune-genomics and development of new cancer therapy for ovarian cancer, we found several immunosuppression related genes in mouse ovarian cancer model with both or either of oncogenes and onco-suppressor genes transfected mouse ovarian cancer cell lines. And we found tumor antigen specific immunosuppressive genes by repeating injections OVA overexpressed ovarian cancer cell line. Lastly we could detect some immunosuppressive function of these genes in vitro and vivo mouse model and find a new potential target of ovarian cancer treatment.

Free Research Field

婦人科腫瘍学