Verification of possible iatrogenic epimutations by artificial reproductive technologies.

2017 Fiscal Year Final Research Report

• Project/Area Number: 26293365
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: National Center for Child Health and Development
• Principal Investigator: HATA KENICHIRO 国立研究開発法人国立成育医療研究センター, 周産期病態研究部, 部長 (60360335)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: エピゲノム / DNAメチル化

Outline of Final Research Achievements

It is suggested that the early embryo culture accompanying artificial reproductive technologies (ART) may cause iatrogenic epimutations and could cause genomic imprinting disorders. However, molecular epidemiological studies do not show a clear relationship between the two. Therefore, we analyzed the DNA methylation in the whole genome, focusing on areas other than genomic imprinting. The epigenetic analysis result by "genetic factors (SNP etc.)" were removed and epigenetic data were effectively normalized. Then, we performed various statistical analyzes. So far, no obtained analysis results suggest possible relation between the infants by ART and the infants outcome of spontaneous pregnancy.

Free Research Field

産婦人科学、分子生物学、ゲノム医学