Analysis for the role of cell competition in the tumorigenesis and treatment strategy of nasopharyngeal carcinoma

2017 Fiscal Year Final Research Report

• Project/Area Number: 26293367
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Kanazawa University
• Principal Investigator: Yoshizaki Tomokazu 金沢大学, 医学系, 教授 (70262582)
• Co-Investigator(Kenkyū-buntansha): 脇坂 尚宏 金沢大学, 医学系, 准教授 (70377414) ; 近藤 悟 金沢大学, 大学病院, 講師 (70436822)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 上咽頭癌 / EBウイルス / LMP1 / エクソソーム / 腫瘍微小環境

Outline of Final Research Achievements

Compensative growth is a concept that neighboring cell competes each other, and the winner cells in cell competition, without invasive property, take place of the looser cells. We analysed the role of cell competition in the pathogenesis of nasopharyngeal carcinoma (NPC). SPARC is anti-apoptotic factor that is usually expressed in the cell competition looser cells. In NPC tumor tissue, SPARC expression is observed in the tumor surrounding cells. LMP1 is a primary oncogene encoded by Epstein-Barr virus, a causative agent of NPC. We find LMP1 increase the exosome-mediated delivery of HIF1α. Modulation of microenvironment via exosome may play some role in the regulation of cell competition, especially at the initial carcinogenic stage of NPC, and thus, upregulate invasion and metastatic potential of NPC in the early stage.

Free Research Field

耳鼻咽喉科・頭頸部外科