Development of regenerative medicine for head and neck tissues using murine and human iPS cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293371
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Kyoto University (2015-2016); Fukushima Medical University (2014)
• Principal Investigator: Omori Koichi 京都大学, 医学(系)研究科(研究院), 教授 (10233272)
• Co-Investigator(Kenkyū-buntansha): 今泉 光雅 福島県立医科大学, 医学部, 助教 (30554422) ; 吉江 進 福島県立医科大学, 医学部, 研究員 (70705459)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: iPS細胞 / 気道上皮細胞 / 筋細胞

Outline of Final Research Achievements

①Successful differentiation into airway epithelial cells and skeletal muscle cells from murine induced pluripotent stem (iPS) cells were achieved. Differentiated cells were transplanted into tracheal defect or the thyroarytenoid muscle and their survival were confirmed. Further, the cilia and the tight junction were observed in the generated airway epithelial cells.
②The airway epithelial cells were successfully generated from human iPS cells, and generated cells showed the ciliated structure with a motility function.

Free Research Field

頭頸部外科学