Development of portable emergency life support system for long-term cardiopulmonary assist

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293384
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: The University of Tokyo
• Principal Investigator: Isoyama Takashi 東京大学, 医学(系)研究科(研究院), 講師 (20302789)
• Co-Investigator(Renkei-kenkyūsha): FUKUNAGA Kazuyoshi 杏林大学, 保健学部, 准教授 (30366405) ; TAKAI Madoka 東京大学, 大学院工学系研究科, 教授 (40287975) ; SAITO Itsuro 東京大学, 大学院医学系研究科, 特任研究員 (80334225) ; ABE Yusuke 東京大学, 大学院医学系研究科, 准教授 (90193010)
• Research Collaborator: HARA Shintaro ; MAENO Erina
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 心肺補助 / 血液ポンプ / 人工肺 / 抗血栓表面修飾 / 2段昇圧 / リン脂質ポリマー / 架橋型コーティング

Outline of Final Research Achievements

A novel portable heart-lung machine called Emergency Life Support System has been developed using the sequential flow pump which was designed as a built-in blood pump with a new principle of two-stage centrifugal pressurization in one impeller. The hydrodynamic performance at 5L/min against 350mmHg of pump head was obtained at 3,100 rpm, and the pump efficiency was about 14%.
To fabricate a highly stable polymer membrane with blood-compatibility on silicone hollow fibers for oxygenator, a newly designed random copolymer, which consists of phospholipids, siloxane, and cross-link polymers was synthesized. Protein adsorption was suppressed on the polymer-coated silicone surface, and the effect was maintained for 84 days.

Free Research Field

医用生体工学