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2016 Fiscal Year Final Research Report

The analysis of inflammasome activation in extracellular histones

Research Project

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Project/Area Number 26293387
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Emergency medicine
Research InstitutionOsaka Institute of Technology

Principal Investigator

Kawahara Ko-ihi  大阪工業大学, 工学部, 教授 (10381170)

Co-Investigator(Kenkyū-buntansha) 丸山 征郎  鹿児島大学, 医歯(薬)学総合研究科, 教授 (20082282)
伊藤 隆史  鹿児島大学, 医歯(薬)学総合研究科, 講師 (20381171)
森元 陽子  鹿児島大学, 医学部・歯学部附属病院, 助教 (30437967)
三浦 直樹  鹿児島大学, 獣医学部, 准教授 (80508036)
中島 利博  東京医科大学, 医学部, 教授 (90260752)
Project Period (FY) 2014-04-01 – 2017-03-31
Keywords敗血症 / インフラマソーム / ヒストン
Outline of Final Research Achievements

Recently, extracellular histones are damage-associated molecular patterns (DAMPs), which is released by necrotic cells. However, extracellular histones remain unclear as DAMPs. In this study, we focused whether extracellular histones activate inflammasome (IL-1β release) in macrophage cell lines, which are ASC in the presence or absence. Therefore, histones induced IL-1βin macrophage cell-lines in the presence or absence ASC, suggesting that sepsis might enhance in extracellular histones.

Free Research Field

医歯薬学

URL: 

Published: 2018-03-22  

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