Development of brachytherapy for early stage oral cancer using I-125 seeds

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293399
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Miura Masahiko 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (10272600)
• Co-Investigator(Kenkyū-buntansha): 林 良雄 東京薬科大学, 薬学部, 教授 (10322562) ; 吉村 亮一 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (40302864) ; 戒田 篤志 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (40632097) ; 岡本 裕之 国立研究開発法人国立がん研究センター, その他部局等, その他 (90595729)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 小線源治療

Outline of Final Research Achievements

Low dose-rate brachtytherapy is a definitive radiotherapy for early stage oral cancer. Au-198 grains are often used for the therapy; however, their supply has been insufficient since The Great East Japan Earthquake. The objective of this study was to examine whether Au-198 grains could be replaced by I-125 seeds usually used for the prostate cancer treatment. For this purpose, three dimensional absorption dose distribution was simulated and temporo-spatial kinetics of G2 arrest was analyzed. When applied to mold therapy using transient treatment instead of eternal implant, we tentatively propose that Au-198 grains could be replaced by I-125 seeds when ten times more number of I-125 seeds are used compared with that of Au-198 grains.

Free Research Field

放射線腫瘍学