Differentiation and function of Foxp3-negative IL-10-producing regulatory T cells on mucosal bacterial infection

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293400
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Nagai Shigenori 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (50348801)
• Co-Investigator(Kenkyū-buntansha): 東 みゆき 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (90255654)
• Co-Investigator(Renkei-kenkyūsha): YOSHIMURA Akihiko 慶應義塾大学, 医学部, 教授 (90182815)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: IL-10 / ヘルパーT細胞

Outline of Final Research Achievements

Since Foxp3-negative, IL-10-producing regulatory T (Tr1) cells are quite important for the suppression of chronic inflammation, I tried to investigate the regulatory mechanisms of Tr1 differentiation. When I added the inhibitor of PI3K, a kind of lipid kinases, in Tr1 differentiation by IL-27, I was able to suppress Tr1 differentiation. In contrast, Tr1 differentiation was enhanced when the PI3K pathway was augmented. These results suggest that PI3K pathway positively regulates the differentiation of IL-27-induced Tr1 cells.

Free Research Field

免疫学