2016 Fiscal Year Final Research Report
Differentiation and function of Foxp3-negative IL-10-producing regulatory T cells on mucosal bacterial infection
Project/Area Number |
26293400
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Pathobiological dentistry/Dental radiology
|
Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
Nagai Shigenori 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (50348801)
|
Co-Investigator(Kenkyū-buntansha) |
東 みゆき 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (90255654)
|
Co-Investigator(Renkei-kenkyūsha) |
YOSHIMURA Akihiko 慶應義塾大学, 医学部, 教授 (90182815)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | IL-10 / ヘルパーT細胞 |
Outline of Final Research Achievements |
Since Foxp3-negative, IL-10-producing regulatory T (Tr1) cells are quite important for the suppression of chronic inflammation, I tried to investigate the regulatory mechanisms of Tr1 differentiation. When I added the inhibitor of PI3K, a kind of lipid kinases, in Tr1 differentiation by IL-27, I was able to suppress Tr1 differentiation. In contrast, Tr1 differentiation was enhanced when the PI3K pathway was augmented. These results suggest that PI3K pathway positively regulates the differentiation of IL-27-induced Tr1 cells.
|
Free Research Field |
免疫学
|