Molecular mechanisms of periodontal diseases and systematic diseases associated with periodontal diseases by periodontal pathogens

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293401
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Okayama University
• Principal Investigator: OHARA Naoya 岡山大学, 医歯(薬)学総合研究科, 教授 (70223930)
• Co-Investigator(Kenkyū-buntansha): 中山 真彰 岡山大学, 医歯(薬)学総合研究科, 助教 (10579105) ; 大原 直子 岡山大学, 医歯(薬)学総合研究科, 助教 (80301365) ; 井上 哲圭 岡山大学, 医歯(薬)学総合研究科, 助教 (20223258)
• Research Collaborator: TAGUCHI Yuko ; KANO Konami
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 歯周病原細菌 / 歯周病 / ジンジパイン / PI3K/Akt

Outline of Final Research Achievements

Periodontal diseases are chronic oral bacterial infectious diseases. In our study, Porphyromonas gingivalis, which is one of major oral pathogens, produces cysteine proteases called as gingipains. Gingipains attenuate PI3K/Akt signaling pathway, and which is associated with their protease activity from extracellular interaction without invasion of this organisms. Moreover, several downstream proteins of Akt, which are GSK3, mTOR, Bad, PRAS40, and MDM2, are also changed the their phosphorylation level by gingipains in gingival epithelial cells. On the basis of the results, their physiological activity might be dysregulated by gingipains in parallel with inactivation of PI3K/Akt in the cells.

Free Research Field

細菌学、感染症学