2017 Fiscal Year Final Research Report
Research on the Effect of Bone Quaility (Collagen) on Bone Metabolism and Its Mechanism
| Project/Area Number |
26293408
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
青柳 裕仁 新潟大学, 医歯学系, 助教 (30460140)
加来 賢 新潟大学, 医歯学系, 准教授 (30547542)
長澤 麻沙子 新潟大学, 医歯学系, 助教 (40612239)
秋葉 陽介 新潟大学, 医歯学総合病院, 講師 (70547512)
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| Research Collaborator |
MUBARAK Suliman
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | コラーゲン / クロスリンク / 骨質 / 骨移植 / デンタルインプラント |
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| Outline of Final Research Achievements |
An in Vitro experiment using cultured cells was first conducted in order to analyze the influence of bone tissue collagen crosslink formation failure on osteoblast / osteoclast activity. As a result, in the cell culture system, the decrease in the amount of crosslink in the matrix increased the activity of osteoblasts and decreased the activity of osteoclasts. Serum bone formation markers increased in vivo and bone resorption markers tended to decrease. Furthermore, bone grafting experiments and implant installation experiments using an animal model of cross link formation failure resulted in bone formation around transplanted bone faster than control. A large amount of immature bone was formed around the implants earlier than the control.
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| Free Research Field |
補綴歯科学
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