A study of materials property and osteoconductive capacity of bone substitutes

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293417
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Tohoku University
• Principal Investigator: Suzuki Osamu 東北大学, 歯学研究科(研究院), 教授 (60374948)
• Co-Investigator(Kenkyū-buntansha): 穴田 貴久 東北大学, 歯学研究科(研究院), 准教授 (30398466) ; 増本 博 東北大学, 学内共同利用施設等, 教授 (50209459) ; 川井 忠 東北大学, 大学病院, 助教 (50547263) ; 井樋 栄二 東北大学, 医学(系)研究科(研究院), 教授 (80193465)
• Co-Investigator(Renkei-kenkyūsha): ARAI FUMIHITO 名古屋大学, 大学院工学研究科, 教授 (90221051)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 生体材料 / 組織工学 / 骨再生

Outline of Final Research Achievements

The present study was designed to investigate as to whether calcium phosphate in matrix polymer materials affects oriented bone formation. Octacalcium phosphate without the matrix stimulated macrophage-like cells migration. The presence of gelatin controls the crystallite size and the hydrolysis rate. Octacalcium phosphate in gelatin matrix affects the production of oriented bone formation in rat calvaria defect. The composite stimulated the formation of cortical bone having strength compatible to natural bone in rabbit tibia defect (push-in-test). The presence of octacalcium phosphate in the matrix material could be associated with the quality of newly formed bone.

Free Research Field

生体材料工学