Development of new therapies targeting SHH in oral cancer jaw bone destruction and its application to personalized medicine

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293428
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Okayama University
• Principal Investigator: Tsuyoshi Shimo 岡山大学, 医歯(薬)学総合研究科, 准教授 (40362991)
• Co-Investigator(Kenkyū-buntansha): 吉岡 徳枝 岡山大学, 医歯(薬)学総合研究科, 助教 (50362984) ; 栗尾 奈愛 岡山大学, 大学病院, 医員 (80622141)
• Co-Investigator(Renkei-kenkyūsha): KURIO Naito 岡山大学, 大学病院, 医員 (80622141)
• Research Collaborator: NAGATSUKA Hitoshi 岡山大学, 医歯薬学総合研究科, 教授 (70237535)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 口腔扁平上皮癌 / 破骨細胞 / ヘッジホッグ

Outline of Final Research Achievements

Oral squamous cell carcinoma frequently invades into the maxilla and the mandible, and that is associated with a worse prognosis. Sonic hedgehog (SHH) signaling contributes to the development, we found that SHH was not expressed in normal oral gingiva, but highly expressed in tumor cells that had invaded the bone matrix. On the other hand, the hedgehog receptor and the signaling molecule were highly expressed in the osteoclasts and the progenitor cells. SHH stimulated osteoclast formation and pit formation, and the GPCR is involved in the signaling.

Free Research Field

口腔外科学