Establishment of ECM related Periodontal medicine

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293437
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Periodontology
• Research Institution: Osaka University
• Principal Investigator: Yamada Satoru 大阪大学, 歯学部附属病院, 講師 (40359849)
• Co-Investigator(Kenkyū-buntansha): 森崎 隆幸 国立研究開発法人国立循環器病研究センター, その他部局等, その他 (30174410) ; 竹立 匡秀 大阪大学, 歯学研究科(研究院), 助教 (60452447) ; 村上 伸也 大阪大学, 歯学研究科(研究院), 教授 (70239490)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 歯周医学 / 遺伝子改変マウス / 細胞外マトリックス

Outline of Final Research Achievements

In this study, we investigated common molecules which are expressed and function in periodontal tissue and other organs/tissues to understand molecular pathogenesis of periodontal medicine. It was shown that PLAP-1 which is expressed in periodontal ligament and adipose tissue functions as positive regulator for adipogenesis. PLAP-1 KO mice shows the improvement of HFD-induced overweight and significantly high glucose tolerance and enhanced insulin sensitivity compared to WT mice. HFD-induced alveolar bone resorption in PLAP-1 KO mice were also less. In LDS model mouse, in which TGF-β signal is disordered alveolar bone loss by P.g inoculation was significantly increased, compared to WT. The LDS macrophages showed an up-regulated response to LPS compared to that of WT. These results suggest that PLAP-1 plays important roles in HFD-induced obesity and periodontitis and the abnormality of TGF-β signal may accelerate pathogenesis or progress of periodontitis.

Free Research Field

歯周病学