Investigation into thrombophilia indigenous to Asian populations and establishment of new strategy for preventing thrombosis

2017 Fiscal Year Final Research Report

• Project/Area Number: 26305027
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 海外学術
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Nakamura Gakuen College
• Principal Investigator: TSUDA Hiroko 中村学園大学, 栄養科学部, 教授 (30180003)
• Co-Investigator(Kenkyū-buntansha): 濱崎 直孝 長崎国際大学, 薬学部, 名誉教授 (00091265) ; 隈 博幸 長崎国際大学, 薬学部, 准教授 (40435136)
• Co-Investigator(Renkei-kenkyūsha): NAKAZONO Eri 福岡医療短期大学, 保健福祉学科, 講師 (10343732) ; NOGUCHI Kenta 中村学園大学, 栄養科学部, 助手 (90757494) ; MORISHITA Eriko 金沢大学, 保健学系, 教授 (50251921) ; KATO Kiyoko 九州大学, 医学(系)研究科, 教授 (10253527) ; HAYASHI Tatsuya 三重県立大学, 看護学部, 教授 (00242959) ; OZAKI Yukio 笛吹中央病院, 院長 (30134539) ; MIYATA Toshiyuki 国立循環器病研究センター, シニア研究員 (90183970) ; KOJIMA Tetsuhito 名古屋大学, 医学(系)研究科, 教授 (40161913)
• Research Collaborator: TSUDA Tomohide 株式会社シノテスト, 上席研究員 ; Oh Doyeun CHA University ; Lee Lai Heng Singapore General Hospital ; Bereczky Zsuzsanna University of Debrechen ; Dusse Luci University Federal de Minas Gerais ; Carvalho Maria University Federal de Minas Gerais
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 遺伝性血栓性素因 / 静脈血栓塞栓症 / アジア人 / プロテインS / プロテインC / 国際学術調査

Outline of Final Research Achievements

We established the international investigation network with researchers in Japan, South Korea, Singapore, Hungary, and Brazil to elucidate the genetic risk factor for venous thromboembolism (VTE). Protein S Tokushima mutant allele is found in 4.2% of Japanese VTE patients, PC p.Arg189Trp mutant allele is in 20.5% of Singaporean patients, and PC p.Lys193del mutant allele is in 2.5%, 5.5%, 7.2% of Japanese, South Korean, and Singaporean patients, respectively, however neither of these mutant alleles was found in Hungarian and Brazilian patients, indicating the racial differences in genetic risk factors. The analyses using plasma and hepatocytes revealed that the expression of protein S and protein C is closely related with the metabolism of glucose and apolipoprotein. Finally, the protein S specific activity assay is found to be able to evaluate the thrombophilic state even on medication for direct oral anticoagulants.

Free Research Field

血栓止血学