Global survey analysis of drug-resistant anti-biogram evolution pattern of MRSA

2017 Fiscal Year Final Research Report

• Project/Area Number: 26305034
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 海外学術
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Niigata University
• Principal Investigator: TERAO Yutaka 新潟大学, 医歯学系, 教授 (50397717)
• Co-Investigator(Kenkyū-buntansha): 土門 久哲 新潟大学, 医歯学総合病院, その他 (00594350) ; 石田 陽子 新潟大学, 医歯(薬)学総合研究科, 研究員 (10377187) ; 小田 真隆 京都薬科大学, 薬学部, 教授 (00412403) ; 上原 良雄 新潟大学, 医歯(薬)学総合研究科, その他 (60346723)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 誤嚥性肺炎

Outline of Final Research Achievements

Staphylococcus aureus is frequently separated from aspiration pneumonitis lesions of the elderly and oropharynx. Staphylococcus aureus is recognized as an intractable bacterial species by being tolerated by the frequent use of antibiotics and called"Methicillin-resistant Staphylococcus aureus (MRSA)". An analysis experiment of bacterial genes was performed using collected a lot of MRSA bacterial strains. As a result, in addition to the conventional determinant of MRSA resistance evolution, "enhancement of drug resistance by uptake of foreign genes", "mutation at the chromosomal DNA level of MRSA itself" is also involved in tolerance I got a suggestion. Also, there was a certain pattern in the evolution of tolerance, suggesting that it can be illustrated by an "anti - biogram" model.

Free Research Field

歯学