Evaluation of a clinical study design for PPK analysis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26330049
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Statistical science
• Research Institution: Teikyo University
• Principal Investigator: Nemoto Asuka 帝京大学, 大学院公衆衛生学研究科, 講師 (20722482)
• Co-Investigator(Renkei-kenkyūsha): TANGO Toshiro 帝京大学, 大学院公衆衛生学研究科, 教授 (70124477) ; YAMAOKA Kazue 帝京大学, 大学院公衆衛生学研究科, 教授 (50091038)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 母集団薬物動態解析 / サンプル取得計画 / パラメータ推定精度

Outline of Final Research Achievements

This research aimed to improve the reliability of the estimated population pharmacokineitc (PPK) parameters after assessing the precision and accuracy of the estimates by stochastic simulation and estimation for data obtained by the limited sampling design (LSD). A motivation example was a PPK analysis of blood alcohol concentration after ingestion of alcoholic beverages in Japanese subjects. The precision and accuracy of PPK parameters was evaluated based on estimates from the LSD, compared with the dense sampling design. An additional covariates were identified by using MCMC Bayesian estimation, which allowed incorporation of parameters of a PPK model reported elsewhere as a informative priors.

Free Research Field

情報学