Development of the protein-gene motif dictionary system based on the codon reduced representation

2016 Fiscal Year Final Research Report

• Project/Area Number: 26330250
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Intelligent informatics
• Research Institution: Toyohashi University of Technology
• Principal Investigator: KATO HIROAKI 豊橋技術科学大学, 工学(系)研究科(研究院), 講師 (30303704)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 分子構造情報処理 / 配列モチーフ / タンパク質 / 遺伝子 / コドン縮約表現 / コドン重み行列 / 三次元モチーフ / データベース

Outline of Final Research Achievements

In the present work, the author has developed the protein-gene motif dictionary system which connected from an amino acid sequence motif to the corresponding gene sequence (coding region) and protein 3D structure. I have also proposed the motif codon reduced representation, and applied to the functional site prediction in the genomic sequence. As the result of the EF-hand calcium- binding motif, it is successfully identified two motif sites in TNNC1 which were interrupted by introns.

Free Research Field

分子情報工学・分子生命情報学