2016 Fiscal Year Final Research Report
Development of the program module for the docking between gamma-secretase and APP
| Project/Area Number |
26330341
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Life / Health / Medical informatics
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| Research Institution | Kindai University (2015-2016)
The Institute of Physical and Chemical Research (2014) |
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Principal Investigator |
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| Research Collaborator |
TAKAJI Tatsuya 近畿大学, 生物理工学部
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 分子動力学シミュレーション / REMD / 膜タンパク質 / アルツハイマー病 / γ切断酵素 / APP / 結合 |
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| Outline of Final Research Achievements |
We have developed the program module that is finding the docking interface between large membrane protein and small membrane protein. It is the module in REIN program. We had code it to find the docking interface between a gamma-secretase and a amyloid precursor protein (APP).
①We developed a program module using NAMD. ② We also performed the simulation of a wild type gamma-secretase and a mutant gannma-secretase. The motion of the protein of the mutant was totally different from the wild type. We could get a new insight for gamma-secretase's dynamics. ③ We used the new module for the docking simulation between the gamma-secretase and APP. We are doing more detail analysis now.
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| Free Research Field |
生体分子シミュレーション
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