2016 Fiscal Year Final Research Report
Glycoscience on medaka development toxicity and innate immune function inhibition by silver nanoparticles
| Project/Area Number |
26340030
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Toyo University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 銀ナノ粒子 / メダカ / 糖鎖 / 免疫 / 生態リスク |
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| Outline of Final Research Achievements |
Ecotoxicity of nanomaterials is one of the international concerns. Silver nanoparticles, which account for about half of the international market as health and hygiene products, are considered to be one of the most ecological risk chemicals, since they have antibacterial activity in particular. In this study, we investigated the influence of silver nanocolloid (SNC), which is considered to be frequently used as silver nanoparticles, on embryo development and on innate immunity to medaka. From analyses of microarray and quantitative PCR, gene expressions related to immunity, biological defense mucosa etc. were disrupted by SNC exposure. Infection experiments with Edwardsiella tarda revealed that the infection of medaka adults increased due to SNC exposure.
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| Free Research Field |
生態毒性学
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