The role of thyroid hormone function in different brain regions during brain development and the development of novel methods to measure the effect of environmental chemicals.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26340036
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: Kanagawa University of Human Services (2015-2016); Gunma University (2014)
• Principal Investigator: IWASAKI Toshiharu 神奈川県立保健福祉大学, 保健福祉学部, 教授 (80375576)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 甲状腺ホルモン / 環境化学物質 / 脳発達

Outline of Final Research Achievements

To study the effect of thyroid hormone (TH) and its receptor (TR) during brain development, we analyzed the hypo-thyroid model animals including transgenic mice expressing a mutant human TR specifically in cerebellar Purkinje cells. These mice showed abnormal cerebellar morphogenesis and motor coordination defect.
We also investigated the effect of environmental chemicals during brain development including developmental origins of health and disease (DOHaD). We analyzed not only environmental chemicals but also soy bean polyphenols and gadolinium-based contrast agents. We found that each chemical showed different effects through different pathways to the brain function. We found that PFOS may disrupt dendrite arbolization through a system other than genomic pathway.

Free Research Field

複合新領域　　内分泌生理学