2016 Fiscal Year Final Research Report
Cell death mechanism by RNA oxidative signal transduction
| Project/Area Number |
26340040
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 酸化ストレス / RNA 酸化 / ８ーオキソグアニン / アポトーシス |
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| Outline of Final Research Achievements |
As oxygen is consumed in brain, reactive oxygen species are generated and are predicted to be a cause of alzheimer disease. In this research, we studied oxidation of RNA and removal of the oxidative RNA.
Human Auf1 protein, a oxidative RNA specific binding protein, was examined whether it had roles in the induction of apoptosis. It was found that Auf1 protein played a role in oxidative RNA degradation. In cells lacking Auf1 protein, apoptosis was repressed. In yeast, Gtr1 protein was found to be involved in excretion of ROS.
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| Free Research Field |
分子生物学
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