2016 Fiscal Year Final Research Report
Study of functional foods as incretin effects for metabolic syndrome
| Project/Area Number |
26350118
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Mukogawa Women's University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | メタボリックシンドローム / インクレチン / GLP-1 / DPP-4 / 植物由来成分 / 肥満 / 腎障害 |
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| Outline of Final Research Achievements |
SHRSP.Z-Lepr fa /IzmDmcr rats (SPZF) show hypertension, hyperphagia, obesity, dyslipidemia, and insulin resistance. Many reports have suggested that glucagon-like peptide-1 (GLP-1) and dipeptidyl peptidase-4 (DPP-4) affect various organs. We observed the expression of GLP-1 and DPP-4 in SPZF rats.In this study, we have shown the effects of incretin may relate to the phenotype in metabolic syndrome status in SPZF.
There are many reports that natural products have numerous health benefits, including protection against cardiovascular disease. Treatment with sake lees significantly increased the GLP-1 receptor expression than in control. Serum active GLP-1 level in peptide fraction of sake lees group was significantly increased than in control. Sake lees attenuated the development of renal damage through GLP-1 and antioxidant activities in SHRSP.
Further studies are needed in order to clarify the effects of the fuctional foods through the incretin
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| Free Research Field |
食品機能学
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