Effect to an immune cell of new soy isoflavone for the purpose of the metabolic syndrome prevention

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350124
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: The University of Tokushima
• Principal Investigator: SHUTO Emi 徳島大学, 大学院医歯薬学研究部(医学系), 講師 (10512121)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: メタボリックシンドローム / 慢性炎症 / 大豆イソフラボン

Outline of Final Research Achievements

Because it was reported that the T cell which was an immune cell controlled the basic condition of a patient, and the concept that various lifestyle diseases produced from chronic inflammation attracted attention of onset mechanism of the metabolic syndrome, I did it with the chronic inflammation target through a T cell concerned with the onset of the metabolic syndrome and tried that I elucidated onset mechanism of new metabolic syndrome.
After giving it, and examining Equol using a diet induced obesity mouse by the Western food of 45% of lipid energy ratios, I found that the differentiation polarity of the macrophage in the epididymis fat become the M2 predominance, and improve an insulin signal affected by a high-fat diet.

Free Research Field

栄養免疫