New risk assessment method for chemicals in foods cosidering lifestlye disease and eating habit

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350125
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: University of Shizuoka
• Principal Investigator: Masuda Shuichi 静岡県立大学, 食品栄養科学部, 准教授 (40336657)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 遺伝毒性 / 生活習慣病 / 食習慣 / アクリルアミド / DNA損傷性 / 染色体異常誘発性 / 糖尿病 / アルコール

Outline of Final Research Achievements

Acrylamide (AA) is a carcinogen in food. AA is metabolized to glycidamide (GA), more strong carcinogen, by CYP2E1. It has been reported that gene and protein expression of CYP2E1 are induced by diabetes or ingestion of alcohol. Consequently, diabetic condition or alcohol intake state may change the genotoxicity of AA. In this study, we examined the change of AA genotoxicity in diabetic condition and alcohol intake state using genotoxicity tests. Type I diabetic model mice and alcohol-ingested mice were oral-administered with AA. The micronuclei frequency in bone marrow erythrocytes and DNA damage in liver and kidney of diabetic and alcohol-ingested mice treated with AA were significantly increased compared with normal mice. It is thought that genotoxicity of AA might be increased by metabolism activation to GA with increase in expression of CYP2E1 in diabetic condition and alcohol habit.

Free Research Field

食品衛生学