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2016 Fiscal Year Final Research Report

The molecular nutritional study of relation between vitamin A level and lipid metabolism

Research Project

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Project/Area Number 26350127
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionUniversity of Nagasaki

Principal Investigator

Yamaguchi Noriaki  長崎県立大学, 看護栄養学部, 助教 (80516295)

Project Period (FY) 2014-04-01 – 2017-03-31
KeywordsビタミンA / 肥満 / 脂肪組織 / AMPK / エネルギー消費量 / ビタミンA過剰症
Outline of Final Research Achievements

Vitamin A reduces fat mass and can contribute to the prevention of obesity. In the present study, we investigated how vitamin A reduced fat mass in a high fat-diet (HFD)-induced obese mouse model. The vitamin A-treated HFD mice (VA mice) had a significant reduction in body weight and fat mass. The energy expenditure in the VA mice significantly increased with the activation of AMP-activated protein kinase α (AMPKα) in the white adipose tissue (WAT). However, the intake of vitamin A caused some typical hypervitaminosis A. We suggest that excess intake of vitamin A reduces the fat mass in HFD-induced obese mice through enhancement of energy expenditure by activation of AMPKα in the WAT.

Free Research Field

栄養生理学

URL: 

Published: 2018-03-22  

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