2016 Fiscal Year Final Research Report
Study on reverse cholesterol transport via small intestine by polyphenol
| Project/Area Number |
26350139
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Nihon University (2015-2016)
National Defense Medical College (2014) |
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Principal Investigator |
KONDO Harumi 日本大学, 生物資源科学部, 講師 (80401602)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | コレステロール / ポリフェノール / 動脈硬化 |
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| Outline of Final Research Achievements |
Recently, we have revealed that the cholesterol absorption inhibitor ezetimibe promoted reverse cholesterol transport (RCT) in hamsters.Some polyphenols have reported to enhance cholesterol efflux from macrophages. Several papers reported that curcumin and qercetin inhibited cholesterol absorption in vitro, it remains unclear whether it affects RCT functions. Therefore, we examined whether administration of curcumin or quercetin to hamsters fed a high cholesterol diet regulates RCT from macrophages, but they did not increase RCT.In conclution, curcumin and quercetin did not affect the inhibition of cholesterol absorption and enhance RCT from the macrophages under the condition of our study.
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| Free Research Field |
食品栄養
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