Effects of green tea extract intake during lactation on glucose and lipid metabolism in offspring from undernourished mother during gestation and lactation.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350149
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Aomori University of Health and Welfare
• Principal Investigator: SATO Shin 青森県立保健大学, 健康科学部, 教授 (40310099)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 胎生期低栄養 / 肥満 / AMP活性化プロテインキナーゼ / 炎症 / 植物ポリフェノール

Outline of Final Research Achievements

This study was investigated the effects of green tea extract (GTE) intake during lactation on the lipid and glucose metabolism and inflammation in offspring of dams exposed to protein restriction during gestation; 1) the effects of GTE intake during lactation on the activity of AMP activated protein kinase (AMPK) and macrophage infiltration in the heart of young female offspring, and 2) the effects of GTE on renal damage in adult offspring fed with high fat diet after weaning. We showed that GTE intake during lactation increased plasma insulin concentration and AMPK activity, and that the GTE intake suppressed the infiltration of macrophage in the heart of young offspring. Next, GTE intake during lactation decreased plasma triglyceride concentration and the inflammatory responses in the kidney of adult male offspring. Taken together, GTE intake during lactation was considered to influence the metabolism and inflammatory responses of offspring after birth.

Free Research Field

栄養生化学