Alteration of glycan-related gene expressions by the supplementation of products derived from cartilage

2017 Fiscal Year Final Research Report

• Project/Area Number: 26350153
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: University of Niigata Prefecture
• Principal Investigator: KAMIYAMA Shin 新潟県立大学, 人間生活学部, 准教授 (70525401)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 糖鎖 / 軟骨 / コラーゲンペプチド / 関節リウマチ / グリコサミノグリカン / グルコサミン

Outline of Final Research Achievements

The present study revealed that the two typical collagen dipeptides, prolyl-hydroxyproline (Pro-Hyp) and hydroxyprolyl-glycine (Hyp-Gly), increase the expression of type II collagen and chondroitin sulfate proteoglycan and promote early chondrogenesis in ATDC5 cells. Further, chicken type II collagen peptides and glucosamine had synergistic effects on the arthritis score and synovial inflammation in SKG mice. In contrast, administration of chicken type I collagen peptides or its constituent amino acids worsened collagen-induced inflammatory arthritis in DBA/1J mice. These findings indicate that supplementation of type II collagen peptides may have beneficial effects on rheumatoid arthritis via oral tolerance rather than stimulation of chondrogenesis unlike type I collagen peptides.

Free Research Field

栄養学、食品機能学