2016 Fiscal Year Final Research Report
Effect of Administration of Rare Sugar D-Allose And Exploratory Research on Nutritional Therapy in NASH Onset Prevention
| Project/Area Number |
26350158
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Eating habits
|
|---|
| Research Institution | Fukuoka Women's University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 非アルコール性脂肪性肝炎 / モデル作製法 / 炎症状態 / STAMマウス |
|---|
| Outline of Final Research Achievements |
By utilizing STAM mice, we tried to clarify the action mechanism of NASH preventive effect through the administration of D-allose and vitamin E. Also, we examined the combined effect of the simultaneous administration of D-allose, vitamin E, leucine and isoleucine, which until now have shown administration effect.
In the clarification of the action mechanism, as a result of attempting a comprehensive metabolism-related genetic analysis, the gene expression level of Serum Amyloid A1 was greatly changed, and the impact of D-allose administration was observed. On the other hand, the combined effect of various nutrients was not observed. In addition, the latest results show problems in the modeling, such as the onset degree of STAM mice not being stable and occasional appearance of dead specimens, and we have concluded that a re-examination is necessary after resolving these issues.
|
| Free Research Field |
栄養学
|
