2016 Fiscal Year Final Research Report
Characterization of AhR ligands from food materials and application for evaluation of well-balanced diet by their activity value
| Project/Area Number |
26350168
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Matsuyama University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 食品 / 食生活 / 食事バランス |
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| Outline of Final Research Achievements |
The activation of the aryl hydrocarbon receptor (AhR) induced by the extracts of 60 food materials, including cereals, tubers and roots, beans, and nuts, was evaluated using a reporter gene assay. Many of the tested samples induced AhR activity; in particular, cereals, vegetables, and nuts, which contribute to a balanced diet, resulted in marked activity. The extracts of walnut and adzuki bean had an especially high AhR activity. To characterize the substances responsible for AhR activation, the constituents of the respective extracts were identified. Fourteen compounds from adzuki bean extract and 29 compounds from walnut extract were isolated and identified. Among these compounds, valoneic acid dilactone methyl ester had notable AhR activation.
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| Free Research Field |
生薬学，天然物化学，食品化学
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