2016 Fiscal Year Final Research Report
Effect of PS-B1 (a fermented product cultured from soybean milk using lactic acid bacteria) on hair growth in vivo
| Project/Area Number |
26350171
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Eating habits
|
|---|
| Research Institution | Nagasaki International University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 乳酸菌 / 発酵 / バイオジェニクス / 毛髪 / 発毛 |
|---|
| Outline of Final Research Achievements |
The effect of PS-B1 (a fermented product cultured from soybean milk using lactic acid bacteria) on hair growth in vivo was examined by topical application of PS-B1 on the shaved dorsal skin of 4-week-old male C57BL/6 mice. The 20% ethanol solutions which included PS-B1 (5%, 15% and 30%), PBS (30%) and soybean milk (30%), respectively, were prepared as application liquids and 50 μL of each liquid was applied to the back of mice (n=10) once a day until hair growth of all mice was completed (8 months). From the picture analysis of dorsal skin, application of PS-B1 induced earlier telogen to anagen conversion as compared to those observed the vehicle treatments. Furthermore, the increase of expression of growth factors implicated in the regulation of hair growth (FGF-2 and KGF) were found as a result of the PCR analysis of the cultivation human follicle dermal papilla cells which stimulated by PS-B1. These results suggested that PS-B1 contains hair growth promoting substances.
|
| Free Research Field |
薬学
|
