• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2016 Fiscal Year Final Research Report

Control mechanism with glial transmitters in cerebellar development

Research Project

  • PDF
Project/Area Number 26350498
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionToyohashi University of Technology

Principal Investigator

Yoshida Sachiko  豊橋技術科学大学, 工学(系)研究科(研究院), 講師 (40222393)

Co-Investigator(Renkei-kenkyūsha) FUKUDA Atsuo  浜松医科大学, 医学部, 教授 (50254272)
Project Period (FY) 2014-04-01 – 2017-03-31
Keywords小脳分化 / 自閉症 / プルキンエ細胞 / 神経伝達物質
Outline of Final Research Achievements

Some HDAC inhibitors including Valproate and SAHA, and chlorpyrifos were observed to induce the alteration of Purkinje cell development and excess folding at V/VI lobule of cerebellum. Valproate and Chrolpyrifos are known as the inducer of autism. Also these chemicals increased in developing cerebellar cortex both Reelin expression which would relate to neuronal migration, and ATP release which would relate to synaptogenesis. The critical concentration and critical period of VPA administration was 300 mg/kg maternally and embryonic day 16, respectively. We developed newly high sensitive enzyme-linked photo assay system with 10 msec time resolution.

Free Research Field

神経科学

URL: 

Published: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi