Mechanobiology of tumor interstitial fluid pressure, angiogenesis, lymphangiogenesis, and Extracellular Matrix (ECM)

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350500
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Okayama University
• Principal Investigator: Inagaki Junko 岡山大学, 医歯薬学総合研究科, 助教 (90271056)
• Co-Investigator(Renkei-kenkyūsha): NARUSE KEIJI 岡山大学, 医歯薬学総合研究科, 教授 (40252233)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ADAMTS1 / 腫瘍内圧 / 細胞外マトリックス / 血管新生 / リンパ管新生

Outline of Final Research Achievements

A disintegrin and metalloprotease with thrombospondin type I motifs 1 (ADAMTS1), a member of the matrix metalloproteinase family, inhibits angiogenesis and lymphangiogenesis. ADAMTS1 in endothelial cells is induced by hypoxia and mechanical stress such as blood wall shear stress. We investigated the effects of tumor interstitial fluid pressure (TIFP) on the expression of ADAMTS1 in the tumor tissues. Stromal ADAMTS1 was mainly expressed in neovascular endothelial cells. It was suggested that stromal ADAMTS1 might implicate in vascular fragility and rarefaction, and elevation of TIFP.

Free Research Field

生化学