Micro-Tomographic Visualization (Multi-Functional OCT) of Visco-elastic Properties inside Osteoarthritic Cartilage

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350510
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Osaka City University
• Principal Investigator: Saeki Souichi 大阪市立大学, 大学院工学研究科, 准教授 (50335767)
• Co-Investigator(Renkei-kenkyūsha): Daisuke Furukawa 大阪市立大学, 大学院工学研究科, 博士研究員 (80774760)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 生体医工学 / バイオメカニクス / 生体材料学 / 医用生体可視化工学 / 計測工学 / 人間医工学

Outline of Final Research Achievements

The epi-illumination typed Dynamic-OCSA system was built with the target specification. The static and vibration examination, i.e. stress-relaxation and dynamic mechanical analysis respectively, were applied using porcine cartilage collagenase-digested or not. It was proved that time-behavior of strain rate was related with degradation degree. We propose the tomographic diagnosis using the attenuation coefficient of strain rate and depth-gradient of viscoelastic phase, respectively, which can diagnose statistically with significant difference. The viscoelastic parameters of cartilage were estimated by typical compression examination, then it was clarified that the viscosity coefficient was initially deteriorated in early osteoarthritis. Based on a viscoelastic model and estimated parameters, the dynamic meaning was elucidated theoretically. Tomographic diagnosinig system of inverse analysis of viscoelastic parameters was suggested preliminarily by numerical experiment.

Free Research Field

医用生体可視化工学