Preparation of Novel Biodegradable Biomaterials using High-pressure

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350527
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Kagoshima University
• Principal Investigator: Kazuya YAMAMOTO 鹿児島大学, 理工学域工学系, 准教授 (40347084)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 高圧力 / 開環重合 / ナノ粒子

Outline of Final Research Achievements

We examined the development of novel biodegradable biomaterials using hight-pressure. First, the acid-catalysed ring-opening polymerization of gamma-butyrolactone (gamma-BL) was carried out in the presence of methanol as an initiator and trifluoromethanesulfonic acid as a catalyst. As the result, the monomer conversions increased with increasing pressures, indicating that high pressure conditions strongly affected the polymerization manner. Next, we performed the preparation of chitin nanoparticles by regeneration from a chitin/1-allyl-3-methylimidazolium bromide solution through high-pressure process. The morphology of nanoparticles was seen in the SEM image of the sample from the resulting dispersion.

Free Research Field

高分子化学