Development of Innovative Targeting Hybrid Artificial Pulmonary Surfactant Preparations by Nanomedicine

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350534
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Nagasaki International University
• Principal Investigator: SHIBATA Osamu 長崎国際大学, 薬学部, 教授 (10117129)
• Co-Investigator(Renkei-kenkyūsha): NAKAHARA HIROMICHI 長崎国際大学, 薬学部・薬学科, 准教授 (00513235)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 表面・界面物性 / 肺サーファクタント / ナノ医薬品 / インテリジェント・ナノ材 料 / Langmuir単分子膜 / ナノ機能材料 / 呼吸窮迫症候群(RDS) / 偏光変調赤外反射吸収法(PM -IRRAS)

Outline of Final Research Achievements

The model peptide in artificial hybrid pulmonary surfactant (PS) changes its secondary structure from alpha-helix to beta-sheet upon lateral compression. However, in the presence of anionic lipids such as phosphatidylglycerol and palmitic acid, the conversion of the structure is found to prevent from the spectroscopic aspect. And fluorinated compound additive in PS also very effective for PS preparation. The mechanism and function of PS across the interface have been elucidated from the thermodynamic, morphological, and spectroscopic perspectives.　This results will provide a useful preparation of novel artificial hybrid pulmonary surfactant (PS) and also available for extensive respiratory disease (asthma, SARS, COPD et al.).

Free Research Field

総合領域