Development of Novel Antitumor Treatment by Sonodynamically Activated Hydroxyl Functionalized Carbon Nanotubes

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350550
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical systems
• Research Institution: Yokohama College of Pharmacy
• Principal Investigator: FUKAI TOSHIO 横浜薬科大学, 薬学部, 教授 (10057755)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: アポトーシス / 一重項酸素 / 活性酸素種 / 超音波 / 音響化学療法

Outline of Final Research Achievements

In this study, the sonodynamically induced antitumor effect of hydroxyl functionalized carbon nanotubes (OH-CNT) was investigated. Sonodynamically induced antitumor effects of OH-CNT by focused ultrasound were investigated using isolated sarcoma 180 cells and mice bearing ectopically-implanted colon 26 carcinoma. Cell damage induced by ultrasonic exposure was enhanced by five-fold in the presence of 80 uM OH-CNT. The combined treatment of ultrasound and OH-CNT suppressed the growth of the implanted colon 26 carcinoma. Histidine, a reactive oxygen scavenger, significantly reduced cell damage caused by ultrasonic exposure in the presence of CNT OH-CNT. These results suggest that singlet oxygen is likely to be involved in the ultrasonically induced cell damage enhanced by CNT.

Free Research Field

人間医工学