2016 Fiscal Year Final Research Report
Development of toxicity evaluation method of electrical stimulation by cultured cells for safety assessment of BMI and BCI medical equipment
| Project/Area Number |
26350561
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical engineering assessment
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KUWABARA Mariko 九州大学, 大学院医学研究院保健学部門検査技術科学分野, 助教 (80772938)
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| Research Collaborator |
TERASAWA Yasuo (株)ニデック, 研究開発本部人工視覚研究所, 所長
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | BMI / BCI / 医療評価技術 / 細胞毒性 / 電荷注入能力 / 電気刺激 / 安全性評価 |
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| Outline of Final Research Achievements |
We developed an in vitro evaluation system to evaluate the safety of electrical stimulation to the living body by observation of colony formation inhibition of Chinese hamster lung fibroblasts. We also used nerve cultured cells to record nerve activity using fluorescent calcium indicator and microelectrode array. This made it possible to evaluate safety, including whether the function is maintained in vitro. We succeeded in developing an experimental system that uses rabbits to evaluate safety against electrical stimulation for a long time.
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| Free Research Field |
医用工学
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