2016 Fiscal Year Final Research Report
Effect of inspiratory muscle training in patients with heart failure with preserved ejection fraction
| Project/Area Number |
26350566
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 呼吸筋 / HFpEF |
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| Outline of Final Research Achievements |
We examined the relationship between inspiratory muscle weakness (IMW) and exercise intolerance in 40 patients with Heart failure with preserved ejection fraction (HFpEF). IMW was prevalent in 27.5% of patients. Patients with IMW had significantly lower percent vital capacity to normal predicted values (%VC), lower percent knee extensor muscle strength to body weight (%KEMS), and shorter 6-minute walk distance (6-MWD) compared with patients without IMW (all p<0.05). Subgroup analysis showed that IMW was accompanied by a further decrease in 6-MWD in patients with restrictive pulmonary dysfunction (%VC <80%) or lower-limb muscle weakness (median value: %KEMS <30%) (all p<0.05). We concluded that IMW was an additional factor implicated in exercise intolerance in patients with HFpEF, and respiratory muscle training is a potential beneficial intervention in those patients.
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| Free Research Field |
心不全
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