Evaluation and clinical application of exercise program by using a novel measuring method for myocardial triglyceride conten

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350588
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Juntendo University
• Principal Investigator: Shimada Kazunori 順天堂大学, 医学(系)研究科(研究院), 先任准教授 (60327814)
• Co-Investigator(Renkei-kenkyūsha): TAMURA Yoshifumi 順天堂大学, 大学院 医学研究科, 准教授 (80420834)
• Research Collaborator: YAMASHITA Haruyo 順天堂大学, 大学院 医学研究科, 助教 (90534892) ; SAI Eiryu 順天堂大学, 大学院 医学研究科, 助教 (30747415)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 心筋内中性脂肪 / 異所性脂肪 / 心筋MRS法 / 心臓リハビリテーション

Outline of Final Research Achievements

Proton magnetic resonance spectroscopy (1H-MRS) enables to assess ectopic fat. We evaluated myocardial triglyceride (MTG) content measured by 1H-MRS in apparently healthy subjects and patients with left ventricular (LV) hypertrophy. The mean MTG content was 0.85% in healthy subjects. The MTG content was significantly associated with the percent body fat and serum TG, anaerobic threshold, and LV end-systolic volume. The MTG content was significantly higher in the hypertensive heart disease (HHD) group than in the hypertrophic cardiomyopathy (HCM) group. In a multivariate analysis, LV mass volume and diagnosis of HCM or HHD were independent factors of the MTG content. Cardiac rehabilitation could reduce MTG content. 1H-MRS may be useful for assessing the associations between the MTG content and various clinical parameters, including those reflecting obesity, metabolic disorders, cardiac morphology and exercise capacity, noninvasively.

Free Research Field

循環器病学