Effectiveness of pharmacotherapy in stroke rehabilitation and identification of functional molecules implicated neuronal plasticity

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350596
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Fujita Health University
• Principal Investigator: Mizutani Kenmei 藤田保健衛生大学, 藤田記念七栗研究所, 講師 (30351068)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 脳梗塞 / リハビリテーション / 神経可塑性 / 薬物併用療法 / 機能回復

Outline of Final Research Achievements

Recently, it has become widely known that neuronal reorganization in the perilesional cortex contributes to some improvement of hemiparesis after stroke. Therefore, various new treatments have been developed to aid in paralysis recovery. Here, we examined in vivo the effects of administration of an activator of protein kinase C (PKC), combined with exercise on functional recovery. The combination of exercise and PKC activator induced further functional recovery compared with exercise alone, and the behavioral effect seen in the administrated animals was dose dependent. Moreover, combining exercise with administration led to increased phosphorylated proteins and serotonin in the perilesional cortex.

Free Research Field

生化学