Influences of Exercise after Arterial Ligation on Oxidative Stress and Pro-angiogenic Factors - Using a Mouse Model of Lower limb Ischemia -

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350623
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Saitama Prefectural University
• Principal Investigator: Maruoka Hiroshi 埼玉県立大学, 保健医療福祉学部, 教授 (80325985)
• Co-Investigator(Renkei-kenkyūsha): Ishigami Akihito 東京都健康長寿医療センター研究所, 老化制御研究チーム分子老化制御, 研究副部長 (50270658) ; Kanemura Naohiko 埼玉県立大学, 保健医療福祉学部, 教授 (20379895) ; Tanaka Kenichi 埼玉県立大学, 保健医療福祉学部, 准教授 (20281313)
• Research Collaborator: Matumoto Jyunichi 春日部中央総合病院
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 血管新生因子 / 運動 / 虚血モデルマウス

Outline of Final Research Achievements

This study examined the influences of exercise after right femoral arterial ligation on pro-angiogenic factors. Wild-type or Vitamin C knock-out mice were randomized groups (based on the presence/absence of ligation). The oxidative stress level was significantly higher at 1 W and 3 W in the <ligation with exercise> compared to Sham group. HIF-1α values were significantly higher at 3 W in the <ligation with exercise> and <ligation without exercise> compared to Sham group. The values representing the pro-angiogenic factors PGC-1α and IL-6 were significantly higher and those representing the anti-angiogenic factor endostatin were markedly lower in the <ligation with exercise> compared to Sham group. In a mice model of lower-limb ischemia, changes in the oxidative stress level were observed from 1 W. An increased HIF-1α level was also observed at 3 W. In this study, the balance between pro- and anti-angiogenic factors was clarified during a 6-weeks exercise program.

Free Research Field

理学療法学