2016 Fiscal Year Final Research Report
Does a treadmill running exercise contribute to preventing deterioration of bone mineral density and bone quality of the femur in KK-Ay mice, a type 2 diabetic animal model?
| Project/Area Number |
26350637
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Tokoha University (2015-2016)
Hamamatsu University (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 2型糖尿病 / トレッドミル走行 / 骨密度 / 骨質 / 骨代謝 / 糖・脂質代謝 |
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| Outline of Final Research Achievements |
We examined the protective effect of treadmill running exercise on decreasing bone mineral density (BMD) and bone quality in diabetes mellitus using KK-Ay mice, an animal model of type 2 diabetes. It was clarified that running at slow speed for a long duration was more effective to the BMD of the femur than fast speed and short duration in type 2 diabetes, and that glycemic control, insulin sensitivity and fat mass were associated with the mechanism. In addition, it was suggested that a decrease in bone resorption action by exercise was also associated with that. However we could not find the change in microarchitecture of the femur. Further investigations will be necessary to establish the most appropriate exercise program to prevent deterioration of bone quality.
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| Free Research Field |
代謝理学療法学
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