Development of a new preventive/therapeutic strategy for skeletal muscle dysfunction derived from cachexia

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350639
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Nihon Fukushi University
• Principal Investigator: IWATA Masahiro 日本福祉大学, 健康科学部, 准教授 (60448264)
• Co-Investigator(Renkei-kenkyūsha): AKIMOTO Takayuki 早稲田大学, スポーツ科学学術院, 教授 (00351205)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 悪液質 / カヘキシー / 骨格筋 / 萎縮 / 代謝 / メカニカルストレス / 温熱刺激

Outline of Final Research Achievements

In this study, we examined the effects of mechanical stress and heat stress on skeletal muscle dysfunction derived from cachexia. As a result, it was suggested that 1) mechanical stress may induce muscle hypertrophy through promotion of protein synthesis pathway by activation of integrin β1/β3 and mTOR, 2) heat stress may suppress muscle atrophy derived from cachexia through inhibition of protein degradation pathway by inactivation of p38MAPK and FoxO1/3a, and 3) mechanical stress may improve insulin resistance through inactivation of p38MAPK and JNK and activation of AS160/TBC1D1.

Free Research Field

細胞生物学，骨格筋生物学