Elucidation of the functional role of endoplasmic reticulum stress and autophagy for sarcopenia

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350815
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: Tokyo Institute of Technology (2015-2016); Toyohashi University of Technology (2014)
• Principal Investigator: Sakuma Kunihiro 東京工業大学, リベラルアーツ研究教育院, 教授 (60291176)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 加齢 / 骨格筋 / 小胞体ストレス / サルコペニア / オートファジー

Outline of Final Research Achievements

Using senescent mice (24-month-old), I investigated the adaptive changes in endoplasmic reticulum stress-linked molecules in skeletal muscle. Although we observed the marked increase in the amount of IRE-1a and PKCtheta protein in cytosol of aged muscle fibers, these expressing position are not equal at those position of autophagy-linked molecules. Long-term low-protein-diet did not attenuate sarcopenic symptom. Supplementation with resveratrol, which decrease endoplasmic reticulum stress, attenuated muscle atrophy after denervation in mice.

Free Research Field

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