2016 Fiscal Year Final Research Report
Some aspects of surtuin in exercise-associated adaptation of skeletal muscle
| Project/Area Number |
26350818
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Hirosaki Gakuin University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 骨格筋 / 長寿遺伝子 / 萎縮 / 再成長 |
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| Outline of Final Research Achievements |
It is still unclear that physical exercise is associated with a longer life span. Physical-exercise-associated intracellular and extracellular stimuli are diverse. Since physiological and anatomical systems of human body have a potential to adapt to these various stimuli, a sensory system in individual cells remains unknown. The purpose of this study was to investigate whether a longevity gene, so-called surtuin (SIRT), plays a role in skeletal muscle plasticity in response to exercise-associated stimuli using experimental animals and cell culture systems. Evidences of this study suggest that SIRT itself may not have a direct role in the adaptation of skeletal muscle in response to exercise stimuli.
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| Free Research Field |
骨格筋生理学
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