Effect of smoking on alveolar macrophage and pathogenesis of allergy

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350852
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Kyoto Sangyo University
• Principal Investigator: TAKEUCHI Minoru 京都産業大学, 総合生命科学部, 教授 (70257773)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 喫煙 / 肺胞マクロファージ / アレルギー / スギ花粉

Outline of Final Research Achievements

Cryptomeria Japonica pollen (CJp) is known as an allergen but not cleared to innate immunity in the lung. We reported that cigarette smoke (CS) inhibited immune functions of alveolar macrophage (AM). CJp and CS are inhaled into the lung and contact with AM. However, it is not fully understood whether CJp and CS affect to AM and neutrophils (Neu) infiltration to the lung. Therefore, we investigated the effect of CJp and CS on AM and Neu in the lung. The induced Neu to the lung by the both of increased mRNA expressions of these cytokines and chemotactic activity of CJp caused lung inflammation, and CS inhibited the influx to alveolar space in the lung of Neu and Neu stay to interstitial tissue in the lung by these functional suppressions of Neu and AM. These results suggest that CS may inhibit secondly immune response in the lung and exacereblate allergy inflammation in the lung.

Free Research Field

応用健康科学