Investigation of improvement of insulin resistance by probiotics

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350871
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Juntendo University
• Principal Investigator: Kanazawa Akio 順天堂大学, 医学部, 准教授 (30407259)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 腸内フローラ / プロバイオティクス / インスリン抵抗性

Outline of Final Research Achievements

Seventy Japanese patients with type 2 diabetes were randomised to two groups: the probiotic group drank Lactobacillus casei strain Shirota-fermented milk for 16 weeks, while the control group ingested no probiotics. At the end of the study, the fecal counts of the Lactobacillus in the probiotic group were significantly higher than in the control group. Intriguingly, the total count of blood bacteria was significantly lower in the probiotic group [2.0(1.0-3.0)/6.0(3.0-12.0) cells /ml, P<0.05]. Our results showed that probiotic administration reduced bacterial translocation in Japanese patients with type 2 diabetes mellitus.

Free Research Field

代謝内分泌学